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Geldanamycin(NSC 122750)

Geldanamycin(NSC 122750)

Product Details:

13 USD ($)/Milligram

Geldanamycin(NSC 122750) Price And Quantity

  • 13 USD ($)/Milligram
  • 20 Ton
  • 6.00 - 16.00 USD ($)/Milligram

Geldanamycin(NSC 122750) Trade Information

  • Shanghai China
  • Telegraphic Transfer (T/T)
  • 600 Ton Per Month
  • 3 Days
  • Within a certain price range free samples are available
  • 10mg/bottle
  • Australia North America South America Western Europe Africa Middle East Eastern Europe Central America Asia
  • All India
  • COA

Product Description

Product name:Geldanamycin(NSC 122750)




Description: Geldanamycin is a benzoquinone ansamycin antibiotic which binds heat shock protein 90 (Hsp90) and its paralog GRP94, altering their actions. Through its interaction with these chaperones, geldanamycin indirectly affects numerous client proteins with roles in diverse cellular processes, including gene expression, cell proliferation, apoptosis, and angiogenesis. For example, geldanamycin inhibits c-jun expression in human colon adenocarcinoma HT29 cells (IC50 = 75 nM), inhibiting AP-1 binding. It also reduces signaling through mitogenic signaling proteins and interferes with steroid receptor function. Inhibitors of Hsp90, including geldanamycin, show promise in cancer therapy.

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