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Demethylchlortetracycline and Lederle

Demethylchlortetracycline and Lederle

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Product name:Demeclocycline/Declomycin/demethylchlortetracycline/Lederle




Description: Demeclocycline, a tetracycline antibiotic, inhibits adenylyl cyclase activation after AVP binds to the V2R in the kidney, and thus targets the underlying pathophysiology of SIADH. This therapy is typically used when patients find severe fluid restriction unacceptable and the underlying disorder cannot be corrected. However, demeclocycline is not approved by the US Food and Drug Administration (FDA) or the European Medicines Agency (EMA) to treat hyponatremia, and can cause nephrotoxicity in patients with heart failure and cirrhosis, although this is usually reversible (Singer and Rotenberg, 1973).

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