Synonym:Sildenafil;139755-83-2;Viagra;Sildenafil solution;Revatio;UK-92480;sildenafil Whatsapp;Sildenafile;SiIdenafiI;viagTa;SIDANAFIL;sildenafll;
Description:Sildenafil (Viagra) is an oral medication called a phosphodiesterase-5 (PDE5) inhibitor approved for the treatment of pulmonary arterial hypertension (PAH) in World Health Organization (WHO) Group 1 patients. The goal of this therapy is to improve exercise ability and delay clinical worsening. Research studies showing the effectiveness of the medication included mostly patients with symptoms that were rated as WHO Functional Class II-III.
Sildenafil is marketed as Revatio for PAH and was approved by the United States Food and Drug Administration (FDA) in 2005. Sildenafil is also marketed as Viagra which is FDAapproved for the treatment of erectile dysfunction but not for the treatment of PAH.
Sildenafil, the first US FDA-approved, oral phosphodiesterase type-5 inhibitor, has revolutionized the treatment of erectile dysfunction sine its approval in 1998. Since sildenafil is a potent inhibitor of cyclic guanosine monophosphate in the corpus cavernosum and therefore increases the penile response to sexual stimulation.