Description: Nandrolone facilitates formation of body muscle mass and strengthens the process of osseous tissue development. The main indications for using nandrolone, as well as other anabolic steroids, are abnormal protein anabolism, asthenia, diseases accompanied by pro tein loss, adrenal insufficiency, steroid diabetes, and prolonged condition of sluggishness.
Nandrolone, 17 -hydroxyester-4-en-3-one (29.1.7), is made from estradiol (28.1.17). The phenol hydroxyl group undergoes methylation by dimethylsulfate in the presence of sodium hydroxide, forming the corresponding methyl ether (29.3.1), and then the aromatic ring is reduced by lithium in liquid ammonia, which forms an enol ether (29.3.2). Hydrolyzing this compound with a mixture of hydrochloric and acetic acids leads to the formation of a keto group, and simultaneous isomerization of the double bond from C5 C10 to position C4 C5 gives the desired nandrolone (29.3.3) . Upon necessity of using it in the form of acid esters, the product is acylated by corresponding acid deriva tives.
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