In the most significant clinical studies to date, a daily dose of 78 mg of punicalagins yielded such remarkable benefits as reversing atherosclerosis, reducing high blood pressure, and preventing the adverse cardiovascular consequences of diabetes. Moreover, an important clinical study demonstrated that 280-375 mg of punicalagins per day halted the progression of prostate cancer in men who had failed conventional therapy.26 Life Extension thus recommends 78 mg of punicalagins per day for cardiovascular protection, and 280-375 mg of punicalagins daily to promote prostate health. allergic to other fruits, pollen or nuts.