Product name:Kratom extract
Kratom (Mitragyna speciosa Korth.) is a tall leafy tree, in the family Rubiaceae, and is native to Southeast Asia. It grows in hot, wet tropical areas such as Thailand, where it is generally called kratom. It grows mostly in the southern regions of this country. The leaves have long been for medicinal purposes and as a narcotic drug. It was also classified in Category V of a five category classification of narcotics by the Thai government enacted the Narcotics Act B.E. 2522, placing kratom along with marijuana. This means that it is illegal to buy, sell, import, or growing and harvesting. This law makes planting the tree illegal and requires existing trees to be cut down. However it is not fully effective, since the tree is indigenous to the country and native people prefer to use them. Hence, kratom remains a popular drug in Thailand, especially in southern regions.
The mechanism of action of kratom extract might not act as a competitive antagonist of acetylcholine yet its dominant effect was at the neuromuscular junction and not at the skeletal muscle or somatic nerve.
The methanolic of kratom extract (MS) and mitragynine (MG) decreased the twitch amplitude dependent on time and concentrations on the isolated phrenic nerve hemidiaphragm preparation.