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Product Details:

1000 USD ($)/Bottle

Price And Quantity

  • 500.00 - 2000.00 USD ($)/Bottle
  • 1kg Kilograms
  • 1000 USD ($)/Bottle

Product Description

Product Name:WIN 55,212-2 MESYLATE

Synonyms:WIN 55,212-2 MESYLATE;131543-23-2;WIN 55212-2 mesylate;CS-754;212-2Mesylate;WIN55;WIN 55,212-2

Molecular Formula:C28H30N2O6S

Formula Weight:522.61

CAS No.:131543-23-2

Description:(+)-WIN 55,212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Ki values of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve. This effect is fully counteracted by rimonabant (Item No. 9000484) at a concentration of 10 nM, by decreasing Ca2+ concentrations below 0.2 mM, or by the IP3 receptor antagonist xestospongin C (Item No. 64950) at a concentration of 1 uM. (+)-WIN 55,212-2 (mesylate) induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion (TG) neurons in a calcium-dependent manner with an EC50 value of 26 uM.

Uses:(R)-(+)-WIN 55,212-2 mesylate salt has been used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioural sensitization. It has also been used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/? mice and wild-type (WT) littermate to analyze the levels of CNR1 in the brain.

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