Synonym: Cosyntropin;16960-16-0;Cortrosyn;Tetracosactide Acetate;Tetracosactide Acetae;Cosyntropin fandachem;Tetracosactide
Description:Cosyntropin is a synthetic polypeptide that consists of amino acid residues 1 through 24 of human ACTH, but that has the full biological activity of its parent. Because it is of synthetic origin, it is less allergenic than ACTH of natural origin. Cosyntropin is used as a diagnostic agent in the screening of patients suspected of having adrenocortical insufficiency. Normally, parenteral administration of cosyntropin acts rapidly on the adrenal cortex to effect release of plasma hydrocortisone; when performing the test, the hydrocortisone levels are compared to a control blood sample taken earlier.
Cosyntropin (Cortrosyn) is a polypeptide that consists solely of the first 24 amino acids of corticotropin. It appears to offer an advantage over the naturally occurring hormone in that it has a longer duration of action and lacks the antigenic portion of corticotropin. Although the short cosyntropin test is recognized as a valid screening test to assess adrenocortical insufficiency, the overnight metyrapone test or insulin hypoglycemia test may prove more sensitive.