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Cefazolin sodium(Ancef or Cefamezin or Cefalin or Kefzol or Zolicef or Sodium cefazolin and Sodium cephazolin)

Cefazolin sodium(Ancef or Cefamezin or Cefalin or Kefzol  or  Zolicef  or  Sodium cefazolin  and Sodium cephazolin)

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Product name:Cefazolin sodium(Ancef, Cefamezin;Cefalin;Kefzol;Zolicef;Sodium cefazolin; Sodium cephazolin)

CAS:27164-46-1

MF:C14H15N8NaO4S3

MW:478.5

Description: Cefazolin sodium is a first-generation cephalosporin antibiotic, useful for the treatment of a number of bacterial infections.

Cefazolin (Ancef, Kefzol) is one of a series of semisyntheticcephalosporins in which the C-3 acetoxy function has beenreplaced by a thiol-containing heterocycle here, 5-methyl-2-thio-1,3,4-thiadiazole. It also contains the somewhatunusual tetrazolylacetyl acylating group. Cefazolin wasreleased in 1973 as a water-soluble sodium salt. It is activeonly by parenteral administration.

Cefazolin provides higher serum levels, slower renalclearance, and a longer half-life than other first-generationcephalosporins. It is approximately 75% protein bound inplasma, a higher value than for most other cephalosporins.Early in vitro and clinical studies suggest that cefazolin ismore active against Gram-negative bacilli but less activeagainst Gram-positive cocci than either cephalothin orcephaloridine. Occurrence rates of thrombophlebitis followingintravenous injection and pain at the site of intramuscularinjection appear to be the lowest of the parenteralcephalosporins.

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