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Streptozotocin(STZ or NSC-85998 or Streptozocin or U 9889 and Zanosar)

Streptozotocin(STZ or NSC-85998 or Streptozocin or U 9889 and Zanosar)

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Product name:Streptozotocin(STZ;NSC-85998;Streptozocin;U 9889;Zanosar)

CAS:18883-66-4

MF:C8H15N3O7

MW:265.22

Description: Streptozotocin (STZ) was originally identified in the late 1950s as an antibiotic and was discovered in a strain of the soil microbe Streptomyces achromogenes. In the mid-1960s, STZ was found to be selectively toxic to the beta cells of the pancreatic islets and thus it is used in animal model of diabetes and as a medical treatment for cancers of the beta cells. STZ use in cancer chemotherapy received Food and Drug Administration approval in July 1982 and the drug was subsequently marketed as Zanosar.

Streptozotocin is an unusual aminoglycoside containing a nitrosoamino group produced by Streptomyces achromogenes and discovered in 1959 as an antibiotic. The nitrosoamino group enables the metabolite to act as a nitric oxide (NO) donor. NO is an important messenger molecule involved in many physiological and pathological processes in the body. Streptozotocin is also widely used to induce diabetes in rodent models by inhibition of cell O-GlcNAcase.

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