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RAD140 CAS No.:1182367-47-0

RAD140 CAS No.:1182367-47-0

Product Details:

  • Grade Industrial Grade
  • Physical Form Powder
13 USD ($)/Milligram

RAD140 CAS No.:1182367-47-0 Price And Quantity

  • 13 USD ($)/Milligram
  • 5.00 - 20.00 USD ($)/Milligram
  • 25 Milligram

RAD140 CAS No.:1182367-47-0 Product Specifications

  • Powder
  • Industrial Grade

RAD140 CAS No.:1182367-47-0 Trade Information

  • Shanghai China
  • Telegraphic Transfer (T/T)
  • 300 Milligram Per Day
  • 3 Days
  • Within a certain price range free samples are available
  • 10mg/bottle
  • Central America Asia Australia North America South America Western Europe
  • All India
  • COA

Product Description

Product Name:RAD140


Molecular Formula:C20H16ClN5O2

Formula Weight:393.83

CAS No.:1182367-47-0

Description:RAD140 is an oral nonsteroidal selective androgen receptor modulator (SARM) that cannot be converted to estrogen by aromatase. It has been demonstrated that RAD140 has high AR affinity and target selectivity, showing marked tissue-selective AR agonist activity comparable to natural androgens in breast cancer cells, while lacking agonist activity in prostate cancer cells.

We have recently reported anti-tumor activity of RAD140 in multiple in vivo and in vitro models of AR/ER+ breast cancer as a single agent and in combination with inhibitors of CDK4/6 and mTOR.

Pharmacodynamic investigation indicates RAD140 acted as an AR agonist in breast cancer cells while suppressing ER signaling and reduced ESR1 mRNA expression.

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