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Fludrocortisone acetate

Fludrocortisone acetate

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Product Description

Product name:Fludrocortisone acetate

CAS:514-36-3

MF:C23H31FO6

MW:422.49

Description: Fludrocortisone acetate is the acetate form of the synthetic corticosteroid fludrocortisone, which is a mineralocorticoid receptor agonist. Fludrocortisone acetate (0.1-5 g/animal) promotes sodium retention in rats in a dose-dependent manner with 37% of sodium excreted compared with control when used at a dose of 5 g/animal. Formulations containing fludrocortisone acetate have been used in the treatment of Addisons disease.

Fludrocortisone acetate,21-acetyloxy-9-fluoro-11,17-dihydroxypregn-4-ene-3,20-dione, 9-fluorohydrocortisone (Florinef Acetate), isused only for the treatment of Addison disease and for inhibitionof endogenous adrenocortical secretions. It has up to about 800 times the MC activity of hydrocortisone and about 11 times the GC activity. Its potent activity stimulated the synthesis and study of the many fluorinated steroids. Although its great salt-retaining activity limits its use to Addison disease, it has sufficient GC activity that in some cases of the disease, additional GCs need not be prescribed.


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