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Estradiol Benzoate

Estradiol Benzoate

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Product Description

Product name:Estradiol Benzoate

Synonym:Estradiol Benzoate;50-50-0;BETA-ESTRADIOL 3-BENZOATE;BETA-ESTRADIOL BENZOATE;B-ESTRADIOL-3-BENZOATE;3-Benzoate;Benzoestrofol

Molecular Formula:C25H28O3

Formula Weight:376.5

CAS No.:50-50-0

Appearance:white crystalline powder 

Usage:Promote the growth and development of female reproductive organs


Description:Estradiol benzoate (INN; brand names Agofollin, Diffolisterol,Progynon-B, many others), or oestradiol benzoate (BAN), is asynthetic ester, specifically the 3-benzoyl ester, of the naturalestrogen, estradiol. It was the first form of estrogen to be marketed, patented by Schering-Kahlbaun in 1936 in an oilpreparation for injectable use and introduced later that year asProgynon-B.


Estradiol benzoate Application:

The effects of daily injections of 5 microgram estradiol benzoate (EB) on the patterns of food and ethanol consumption were studied in ovarectomized rats given free access to food, a 10% ethanol solution, and water. EB led to an immediate, but transient, suppression of both food and ethanol intake. The time course and magnitude of these effects were virtually identical.

While the decrease in total food intake was achieved by a permanent decrease in the duration of eating bouts, the decline in total ethanol consumption apparently resulted from decreased rates of licking within bouts. Gradual increases in the frequency of eating and ethanol-drinking bouts allowed total food and ethanol intake to return to baseline within three weeks of the first injection. Total water intake rose three-fold during EB administration and this was due to increases in both the duration and frequency of drinking bouts. The similarity in effects induced by EB on the patterns of food and ethanol intake were discussed in terms of ethanol's caloric property.

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