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AICAR (Acadesine)

AICAR (Acadesine)

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Product Name:AICAR(Acadesine)

Synonym:AICAR;Acadesine;2627-69-2;AICA-RIBOSIDE;AMPK;Arasine;GP 1-110;NSC 105823;AMPK1;Z-RIBOSIDE;AIC-Riboside;5-Aminoimidazole-4-carboxamide riboside

Molecular Formula:C9H14N4O5

Formula Weight:258.23

CAS No.:2627-69-2


Description:Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate).

Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death.

Uses:AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.

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